Signe Heiberg was born in Copenhagen and has been singing since childhood. 

She has already impressed audiences in various opera productions in Germany, Switzerland and Austria.

From the 2021/22 to 2023/24 season, she was a member of the ensemble at Bremerhaven City Theatre. Here she made her role debut as Lady Macbeth in Philipp Westerbarkei's production of Verdi's Macbeth, which was nominated for the German Theatre Prize Der Faust in 2023.

She celebrated further great successes in the title role of Oceane by Detlef Glanert in Katharina Thoma's production and as Floria Tosca in Angela Denoke's production.

In December 2023, she made a very successful debut as Rusalka in a production by Johannes Pölzgutter. In spring 2024, she can be heard again as Die Feldmarschallin in Der Rosenkavalier.

At the Lauritz Melchior International Singing Competition 2024, Signe Heiberg successfully sang her way to the final, where she won 2nd prize and the Audience Award.

In 2019, she made her role and house debut as Amelia in Verdi's Un Ballo in Maschera at the Neue Eutiner Festspiele. She made her debut in Austria as Rosalinde in Die Fledermaus at the 30th anniversary of the Herbsttage Blindenmarkt.

Her impressive repertoire also includes roles such as Desdemona in Otello, Countess Almaviva in Le nozze di Figaro, Agathe in Der Freischütz, Giulietta in The Tales of Hoffmann and Hanna Glawari in The Merry Widow.

 Signe Heiberg began her vocal training at an early age in various choirs and was coached by Prof Helene Gjerris from the age of 16. Three years later, she was accepted into the renowned MGK programme for young musical talent. There she was taught and supported by the opera singer Marianne Rørholm.

After completing her bachelor's degree in singing at the Royal Danish Academy of Music in her hometown of Copenhagen, she moved to Hamburg in 2013. There she studied at the Hamburg University of Music and Theatre in the class of Prof. Carolyn Grace James. She completed her studies in 2016 (also with Prof. James) with the concert exam.

Various masterclasses with KS Brigitte Fassbänder, KS Edda Moser, Senior Vocal Coach Benton Hess, Susanna Eken, Professor Susan McCulloch and Margaret Humphrey Clark complemented her training and furthered her vocal development. 

Signe Heiberg has been working closely with the renowned mezzo-soprano Michaela Schuster since 2017.